Antibiotic-loving bacteria don't just resist drugs, they get a kick out of them


By www.sci-news.com

A team of scientists at the University of Exeter, UK, exposed Escherichia coli (E. coli) bacteria to eight rounds of antibiotic treatment over four days and found the bacteria had increased antibiotic resistance with each treatment.

This had been expected, but the authors were surprised to find mutated E. coli reproduced faster than before encountering the drugs and formed populations that were three times larger because of the mutations.

This was only seen in bacteria exposed to antibiotics — and when the team took the drug away, the evolutionary changes were not undone and the new-found abilities remained.

“Our research suggests there could be added benefits for E.coli bacteria when they evolve resistance to clinical levels of antibiotics,” said University of Exeter Professor Robert Beardmore, lead author on the study.

“It’s often said that Darwinian evolution is slow, but nothing could be further from the truth, particularly when bacteria are exposed to antibiotics.”

“Bacteria have a remarkable ability to rearrange their DNA and this can stop drugs working, sometimes in a matter of days. While rapid DNA change can be dangerous to a human cell, to a bacterium like E. coli it can have multiple benefits, provided they hit on the right changes.”

Prof. Beardmore and co-authors tested the effects of the antibiotic doxycycline on E. coli as part of a study of DNA changes brought about by antibiotics.

The bacteria that subsequently evolved was safely frozen at minus 80 degrees Celsius and the scientists used genetic sequencing to find out which DNA changes were responsible for its unusual evolution.

Some changes are well known and have been seen in clinical patients, like E. coli producing more antibiotic pumps that bacteria exploit to push antibiotics out of the cell. Another change saw the loss of DNA that is known to describe a dormant virus.

“Our best guess is that losing viral DNA stops the E.coli destroying itself, so we see more bacterial cells growing once the increase in pump DNA allows them to resist the antibiotic in the first place,” said study first author Dr. Carlos Reding-Roman.

“This creates an evolutionary force for change on two regions of the E. coli genome.”

“Normally, self-destruction can help bacteria colonize surfaces through the production of biofilms. You see biofilms in a dirty sink when you look down the plughole. But our study used liquid conditions, a bit like the bloodstream, so the E. coli could give up on its biofilm lifestyle in favor of increasing cell production.”

“It is said by some that drug resistance evolution doesn’t take place at high dosages but our paper shows that it can and that bacteria can change in ways that would not be beneficial for the treatment of certain types of infection. This shows it’s important to use the right antibiotic on patients as soon as possible so we don’t see adaptations like these in the clinic,” said co-author Dr. Mark Hewlett.

_____

C. Reding-Roman et al. 2017. The unconstrained evolution of fast and efficient antibiotic-resistant bacterial genomes. Nat. Ecol. Evol. 1: 0050; doi: 10.1038/s41559-016-0050

Source: http://www.sci-news.com/medicine/antibiotics-stimulate-bacterial-reproduction-04581.html


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Monday, May 11, 2026

Over the Counter Approaches That Support Patients Taking Risperidone

Patients taking risperidone for schizophrenia, bipolar disorder, or autism-related behavioral management, along with their caregivers, often benefit from understanding what non-prescription strategies can support treatment outcomes and manage the side effects commonly associated with this atypical antipsychotic. Weight and metabolic management are among the most clinically important non-pharmacological complements to risperidone therapy. Weight gain is a well-documented effect of risperidone, though generally less severe than with olanzapine or clozapine. Patients and families who adopt structured dietary practices including reduced caloric density foods, increased fruit and vegetable intake, and controlled portion sizes from the beginning of treatment have better long-term weight trajectories than those who delay behavioral changes until significant weight gain has already occurred. Regular physical activity provides cardiovascular benefit, supports weight management, and may modestly improve metabolic parameters affected by antipsychotic therapy. For children prescribed risperidone for autism-related irritability, structured physical activity also provides behavioral benefit and supports overall health. Families and caregivers can facilitate outdoor activity, play-based movement, or organized sports as practical complements to pharmacological management. Low-sugar, low-glycemic dietary patterns support the blood glucose stability that can be disrupted by atypical antipsychotics over time. Reducing readily absorbed carbohydrates including sweetened beverages, white bread, and high-sugar snacks while increasing protein and fiber supports more stable glucose levels and reduces the metabolic risk associated with long-term risperidone use. Omega-3 fatty acid supplementation, particularly from fish oil with high EPA content, has anti-inflammatory and metabolic properties that complement antipsychotic treatment. Some research suggests modest benefit for psychiatric symptoms when omega-3 is added to antipsychotic therapy, and the cardiovascular benefits are meaningful for a population at elevated metabolic risk. No significant adverse interaction with risperidone has been established. Consistent and adequate sleep supports psychiatric stability and reduces behavioral dysregulation relevant to autism-related management. Sleep hygiene practices including consistent bedtimes, reduced screen exposure before sleep, and a quiet environment are simple non-prescription supports that can meaningfully affect behavioral outcomes alongside medication. Patients on risperidone who develop constipation as an anticholinergic side effect benefit from fiber supplementation and increased fluid intake as straightforward OTC dietary tools. For patients and caregivers who want practical guidance on OTC and lifestyle strategies compatible with risperidone, reviewing over the counter options combined with risperidone therapy provides actionable self-care guidance. For a broader view of antipsychotic management approaches and how risperidone compares in the full treatment category, antipsychotic medication category patient guides offers informative comparative context.

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