caslireti.blogspot.com: July 2026

Antibiotic-loving bacteria don't just resist drugs, they get a kick out of them

By www.sci-news.com

A team of scientists at the University of Exeter, UK, exposed Escherichia coli (E. coli) bacteria to eight rounds of antibiotic treatment over four days and found the bacteria had increased antibiotic resistance with each treatment.

This had been expected, but the authors were surprised to find mutated E. coli reproduced faster than before encountering the drugs and formed populations that were three times larger because of the mutations.

This was only seen in bacteria exposed to antibiotics — and when the team took the drug away, the evolutionary changes were not undone and the new-found abilities remained.

“Our research suggests there could be added benefits for E.coli bacteria when they evolve resistance to clinical levels of antibiotics,” said University of Exeter Professor Robert Beardmore, lead author on the study.

“It’s often said that Darwinian evolution is slow, but nothing could be further from the truth, particularly when bacteria are exposed to antibiotics.”

“Bacteria have a remarkable ability to rearrange their DNA and this can stop drugs working, sometimes in a matter of days. While rapid DNA change can be dangerous to a human cell, to a bacterium like E. coli it can have multiple benefits, provided they hit on the right changes.”

Prof. Beardmore and co-authors tested the effects of the antibiotic doxycycline on E. coli as part of a study of DNA changes brought about by antibiotics.

The bacteria that subsequently evolved was safely frozen at minus 80 degrees Celsius and the scientists used genetic sequencing to find out which DNA changes were responsible for its unusual evolution.

Some changes are well known and have been seen in clinical patients, like E. coli producing more antibiotic pumps that bacteria exploit to push antibiotics out of the cell. Another change saw the loss of DNA that is known to describe a dormant virus.

“Our best guess is that losing viral DNA stops the E.coli destroying itself, so we see more bacterial cells growing once the increase in pump DNA allows them to resist the antibiotic in the first place,” said study first author Dr. Carlos Reding-Roman.

“This creates an evolutionary force for change on two regions of the E. coli genome.”

“Normally, self-destruction can help bacteria colonize surfaces through the production of biofilms. You see biofilms in a dirty sink when you look down the plughole. But our study used liquid conditions, a bit like the bloodstream, so the E. coli could give up on its biofilm lifestyle in favor of increasing cell production.”

“It is said by some that drug resistance evolution doesn’t take place at high dosages but our paper shows that it can and that bacteria can change in ways that would not be beneficial for the treatment of certain types of infection. This shows it’s important to use the right antibiotic on patients as soon as possible so we don’t see adaptations like these in the clinic,” said co-author Dr. Mark Hewlett.

_____

C. Reding-Roman et al. 2017. The unconstrained evolution of fast and efficient antibiotic-resistant bacterial genomes. Nat. Ecol. Evol. 1: 0050; doi: 10.1038/s41559-016-0050

Source: http://www.sci-news.com/medicine/antibiotics-stimulate-bacterial-reproduction-04581.html

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Friday, July 3, 2026

How to Approach Prednisone and muscle aches With Confidence

Doctors prescribe corticosteroids for a wide range of conditions, from inflammation to autoimmune disorders. Sleep disruption is a frequently reported side effect, especially when doses are taken later in the day. Pregnant or breastfeeding patients should always discuss medication safety with their provider. Chronic conditions such as arthritis or asthma often call for longer treatment planning. Short courses of steroid therapy are generally well tolerated by most adults. Corticosteroids mimic hormones the body produces naturally in the adrenal glands. Immune suppression is a known effect, which is why avoiding sick contacts is often advised. For readers who want a deeper dive, this prednisone and muscle aches covers the specifics in plain language. Nutrition plays a supporting role in recovery, particularly for conditions involving inflammation. Hydration and a balanced diet can support the body during a course of treatment. Gastrointestinal discomfort is one reason many prescribers suggest pairing medication with a meal. Every treatment decision should weigh the benefits against the possible risks for that individual. Missing a dose occasionally is common, but a consistent schedule improves overall outcomes. Tracking symptoms in a simple log helps both patients and doctors evaluate progress. Vaccination schedules sometimes need adjustment while a patient is on immune-modulating therapy. Respiratory conditions may require inhaled or oral steroids depending on severity. Common side effects include appetite changes, mood shifts, and difficulty sleeping. Combining certain drugs without medical guidance can increase the risk of unwanted interactions. Taking medication with food can help reduce stomach discomfort for many patients. Insurance coverage and pricing can vary widely, so comparing options is often worthwhile. Reading the medication guide provided by a pharmacy can clarify proper administration. Blood pressure can rise modestly during treatment, so routine monitoring is a sensible precaution. Those looking for more detail can review this prednisone kidneys for practical guidance. Doctors often recommend tapering the dose gradually rather than stopping abruptly. Every patient metabolizes medication differently, which is why dosing guidelines vary by condition. Weight fluctuation is common and typically stabilizes once the medication course ends. Every patient's situation is different, so personalized medical advice should always guide final decisions.